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Identification of the Route of Action of the Carcinogen 3:2'-Dimethyl-4-aminobiphenyl in the Induction of Intestinal Neoplasia¹

Department of Surgery, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania 19102

Wistar rats were used in the identification of the route of action in the induction of intestinal neoplasia by the carcinogen 3:2'-dimethyl-4-aminobiphenyl. By operative manipulation, segments of the rat colon were defunctionalized and fecal contact with intestinal mucosa was minimized. Rats were given the carcinogen in a convenient dosage schedule, and neoplasia was induced. Interpretation of these experiments suggests that the chemical is absorbed from the injection site; modified, probably in the liver; excreted into the bile; and neoplasia induced by direct contact of feces with the intestinal mucosal cell.

¹ Supported by Grant T-169D of the American Cancer Society.

² Present address: Department of Plastic Surgery, Mt. Sinai Hospital, New York, New York.

³ Present address: Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.

Received 9/ 6/66. Accepted 12/ 1/66.

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