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Cytogenetic Studies in Multiple Myeloma: A Study of Fourteen Cases¹

The Departments of Pathology and Medicine, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140

The bone marrows of fourteen patients with multiple myeloma containing a total of more than twenty scroable metaphase plates in all samples collected were subjected to cytogenetic study. In five of these an abnormal acrocentric marker chromosome with long arms the length of those of the B group was found in a number of the hyperdiploid cells. In two additional patients, this same abnormality may have been present. A single patient had an abnormal submetacentric marker instead of the acrocentric one. Six patients had no abnormality. The incidence of abnormal karyotypes in the marrow of this series of myeloma patients is higher than previously reported and may reflect the result of evaluating a larger sample of cells in metaphase.

¹ Supported by USPHS Grant #CA-08314-02.

² Advanced Clinical Fellow of the American Cancer Society.

Received 11/15/66. Accepted 12/21/66.

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