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The Effect of Exogenously Administered D-Glucosamine Hydrochloride on the Seromucoid Fraction of Tumor-bearing Rats¹

Department of Surgery and the Surgical-Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada

Exogenously administered D-glucosamine hydrochloride had no effect on the level of the various components of the seromucoid fraction of the plasma proteins of the normal rat at the dose level utilized in this study apart from an initial nonspecific elevation of all parameters measured and a persistent mild elevation of protein-bound hexoses after eight days of administration. No explanation is available to account for the latter observation.

Exogenously administered D-glucosamine hydrochloride markedly suppressed the anticipated elevation of the seromucoid fraction of the rat bearing the Walker 256 carcinoma. Possible explanations for this observation are discussed.

No apparent toxic effects of treatment were observed in normal animals, and there was no observable inhibition of growth of Walker 256 carcinoma in rats treated with D-glucosamine hydrochloride during the twenty-day period of observation.

¹ This work was supported by grants from the National Cancer Institute of Canada (NCI No. 226) and the Medical Research Fund of the University of Alberta (MR No. 236).

² Vessie Heckbert Summer Research Student.

Received 7/18/66. Accepted 12/29/66.