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Studies on the Pathogenesis of Plasma Cell Tumors: Effects of Sex Hormones on the Development of Plasma Cell Tumors¹

Research Institute for Skeletomuscular Diseases of the Hospital for Joint Diseases and Medical Center, New York, New York 10035

The effects of sex hormones on the development of plasma cell tumors in BALB/c mice were studied. Mice of both sexes were injected i.p. with mineral oil. Plasma cell tumors in female mice exhibited a lower incidence and a longer period of latency than those of male mice. Testosterone administration to female mice strikingly accelerated development of mineral oil-induced plasma cell tumors and the growth of transplanted tumors. Progesterone administration suppressed tumorigenesis and increased the number of i.p. mast cells in these mice. Gonadectomy of males stimulated and gonadectomy of females retarded the development of plasma cell tumors. These results demonstrate extensive influence of plasma cell tumorigenesis by sex hormones.

¹ This work was supported by the American Cancer Society, Grant No. P-397.

Received 8/15/66. Accepted 12/29/66.

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