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Antigenicity of a Virus-induced Murine Sarcoma (Moloney)

Drug Evaluation Branch, Cancer Chemotherapy, National Service Center, NIH, Bethesda, Maryland 20014

Moloney sarcoma virus rapidly induced sarcomas in newborn BALB/c and CBF (BALB/c x C57BL/6) mice. A significant incidence of regressions of primary tumors was noted. Moloney sarcoma virus release from a transplantable Moloney sarcoma was suggested by the rapid induction of tumor in newborn mice inoculated with lethally irradiated cells (15,000 R). Specific transplantation resistance to Moloney sarcoma was induced by pretreatment of histocompatible hosts with Moloney sarcoma virus preparation or X-irradiated Moloney sarcoma cells. Cross-resistance was demonstrated between Moloney sarcoma and Friend, Moloney, and Rauscher (FMR) leukemia cells, but not with two long-transplanted lymphomas of non-FMR origin. Mice immunized with Moloney sarcoma cells produced humoral antibodies which reacted with FMR leukemia cells by the indirect fluorescence test. Sera from mice immunized with FMR leukemia cells or Moloney sarcoma cells, mixed with Moloney sarcoma virus in vitro neutralized the oncogenic activity of the Moloney sarcoma virus preparation. The results may be explained either by assuming antigenic similarity between FMR leukemia cells and Moloney sarcoma cells, or their causative agents, or by postulating a coexistence of Moloney lymphoma virus and Moloney sarcoma virus in our Moloney sarcoma virus preparation.

¹ United States Public Health Corps.

² Drug Evaluation Branch, National Cancer Institute.

³ Microbiological Associates, Inc., Bethesda, Md.

Received 10/27/66. Accepted 1/ 6/67.