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Serum Lipoproteins in Rats with Tumors Induced by 9,10-Dimethyl-1,2-benzanthracene and with Transplanted Walker Carcinosarcoma 256¹

Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, and Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College, New York, New York

The tumor chemically induced by 9,10-dimethyl-1,2-benzanthracene had 2 pronounced effects upon serum lipoproteins in rats. In the low-density class of lipoproteins floating in a sodium chloride density gradient of 1.063 gm/ml, the flotation (or —sedimentation) class 0–10 (S_f (0–10), usually a single component, was altered such that 2 components appeared after tumors became palpable. In no experiments with normal rats or with rats bearing the transplanted Walker carcinosarcoma 256 was this alteration in S_f 0–10 observed. The presence of the chemically induced tumor resulted in a significant decrease in the quantity of the high-density lipoprotein which floats in a salt gradient of 1.125 gm/ml.

The transplanted tumor, Walker carcinosarcoma 256, also resulted in a significant decrease in the quantity of the high-density lipoprotein (D < 1.125 gm/ml). In addition, this tumor caused a consistent increase in one of the very low-density lipoproteins in the S_f 0–20 class (D < 1.006 gm/ml). The relative amounts of phosphatidylcholine and sphingomyelin were increased in lipids extracted from the very low-density lipoproteins of serum from rats with the Walker tumor. There were relatively more triglycerides in lipids in the low-density lipoproteins when rats had this tumor.

The decreases observed in the high-density lipoprotein (D < 1.125 gm/ml) in sera from rats with either the induced or the transplanted tumors were not influenced by age or by sex.

¹ Supported in part by National Cancer Institute Grant CA 08748.

² Present address: Columbia University, College of Pharmacy, 115 West 68th Street, New York, New York.

Received 9/ 8/66. Accepted 1/31/67.