This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Dachi, S. F. Articles by Urie, E. M. Search for Related Content PubMed PubMed Citation Articles by Dachi, S. F. Articles by Urie, E. M.

Effects of Dimethyl Sulfoxide on Dimethylbenzanthracene-induced Carcinogenesis in the Hamster Cheek Pouch¹

Department of Oral Diagnosis and Oral Medicine, College of Dentistry, University of Kentucky, Lexington, Kentucky 40506

The studies demonstrated that the use of dimethyl sulfoxide (DMSO) as a vehicle for dimethylbenzanthracene in the production of experimental tumors in the hamster cheek pouch, significantly reduced the latent period for tumor production when compared to the usual mineral oil vehicle. No systemic or local changes could be attributed to the DMSO itself, and the morphology of induced tumors was not changed. This finding may be of significance for the possible use of DMSO in other carcinogenesis studies and, particularly, for further investigations of the two-phase phenomenon of carcinogenesis in the hamster cheek pouch.

¹ This investigation was supported by the National Cancer Institute, NIH, under Grant No. CA 07490.

Received 11/18/66. Accepted 2/28/67.