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Acceleration of Growth of Chemically Induced Tumors by Use of Transplantation Technic¹

Bio-Research Institute, Cambridge, Massachusetts 02141

Extensive studies on subcutaneous tumor formation following injection of 3,4,9,10-dibenzpyrene (benzo[rst]pentaphene) have shown that the time of latency following carcinogen injection is, in general, 10 weeks; that 50% tumor incidence is reached in 14 to 15 weeks; and that 100% of the injected animals in most cases have tumors after 25 weeks.

Transplantation of combined carcinogen injection sites from 4 animals 5 weeks after carcinogen injection into 1 secondary host significantly accelerates tumor growth in the secondary recipient. The latency in the secondary host is 3 weeks; 50% tumor yield is reached 4 weeks after transfer of the injection sites, with 100% tumor yield 5 weeks later. The 50% tumor level is thus reached 9 weeks after the original carcinogen injection, an acceleration of 5 weeks. This technic shortens the time required for carcinogen testing and may permit certain conclusions on the nature of the carcinogenic process in vivo.

¹ This work was supported by USPHS Research Grant No. CA-04869-05 (National Cancer Institute), by USPHS General Research Support Grant No. SO1-FR-05525-03 (Division of Research Facilities and Resources), and by grants from the Council for Tobacco Research-U.S.A., and the D. K. Ludwig Foundation.

Received 9/14/66. Accepted 3/ 7/67.