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Evidence of Common Antigenic Properties in Chemically Induced Sarcomas of Mice¹

Sloan-Kettering Institute for Cancer Research, New York, New York 10021

The transplantability of second or third generation methylcholanthrene-induced sarcomas of C57BL/6 mice was tested by subcutaneous inoculation of quantitated cell suspensions of tumors in variously treated syngeneic recipients. Mice which had been previously exposed to one of the tumors (by transplantation followed by the excision of the tumor) were usually resistant to challenge of the same tumor. Of the 5 tumors which were studied, 2 gave complete resistance to challenge, 2 gave partial resistance, and 1 showed no apparent effect. "Immunization" with normal liver had no effect on subsequent tumor transplants. When challenged with a tumor different from the one used for immunization, there was no evidence of cross-resistance. However, cross-resistance was produced by immunization with a mixture of 4 of the tumors followed by challenge with the tumor which had been omitted from the mixture. In this type of experiment there was evidence of cross-resistance against 4 of the 5 tumors, and in 2 of these resistance to challenge was complete.

It is postulated that, as part of individually tumor-specific changes in antigenicity in chemically induced tumors, there are minor antigenic alterations which are multiple and are shared by some but not all tumors of the same etiology. The mechanisms of antigenic alteration that would produce this effect are discussed.

¹ This research was supported in part by NCI Grant CA 08748.

Received 1/13/67. Accepted 3/13/67.

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