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Nucleic Acid and Phospholipid Synthesis in the Regenerating Liver of Tumor-bearing Mice¹

Department of Medicine, University of Minnesota Medical Center, Minneapolis, Minnesota 55455

The metabolic interrelationships between the growth of a rapidly proliferating tissue and of a transplanted tumor were investigated in the same animal. Liver regeneration and tumor growth were studied in C3H mice bearing a transplanted mammary carcinoma.

The rate of radioactive phosphorus incorporation in the DNA, RNA, and phospholipids of the liver and the tumor was determined at intervals of six hours after partial hepatectomy.

The presence of the tumor did not affect significantly the time of onset, but increased markedly the rate of DNA synthesis in the regenerating liver from 24 to 36 hours after the partial hepatectomy. It had no effect on the liver phospholipid and RNA turnover rates. The tumor itself did not show any variation in the rate of ³²P incorporation in phospholipids and RNA throughout the 48-hour study period, but demonstrated an early fall and a subsequent rise in DNA synthesis.

¹ This study was supported by Grants CA-3143, CA-8832, and T4-CA-5158 from the National Cancer Institute, USPHS.

² Instructor in Medicine, University of Minnesota Medical School.

³ Associate Professor of Medicine, University of Minnesota Medical School.

Received 10/ 3/66. Accepted 3/14/67.