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Influence of Pineal Gland on the Growth and Spread of Melanoma in the Hamster¹

Andre and Bella Meyer Laboratory of the Division of Experimental Surgery and Physiology of the Sloan-Kettering Institute for Cancer Research, New York, New York, and the Department of Anatomy, Guy's Hospital Medical School, London S.E.1, England

Pigmented malignant melanoma (M Mel No. 1) was transplanted into the subcutaneous tissue of the dorsum of control, sham-operated, and pinealectomized Syrian hamsters of both sexes and weighing between 80 and 110 gm. Animals from each group were sacrificed at regular intervals and autopsied. The pinealectomized group of hamsters had significantly larger primary tumors and more extensive metastases than the control or sham-operated animals at every phase of the study.

It is felt that these findings are possible indications of a relationship between the pineal gland and growth and spread of pigmented melanomata in hamsters.

¹ This work was partially supported by USPHS Grant CRT 5110.

Received 12/12/66. Accepted 3/28/67.

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