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A Household Cluster of Feline Malignant Lymphoma¹

California State Department of Public Health, Berkeley, California 94704

During a 3-year period, 3 histologically confirmed malignant lymphoma cases and 3 additional clinically diagnosed cases were observed among 34 cats kept for varying lengths of time in the same household. The 3 clinical diagnoses were supported by surgery and necropsy findings consistent with a diganosis of malignant lymphoma. On the basis of existing incidence data, the occurrence of 3 to 6 cases in 34 cats is far higher than would be expected due to chance alone.

The pattern and occurrence of cases may best be explained by horizontal transmission of an infectious agent. There was a continuum of contact from the 1st to the 6th case. One case was not known to be related to any of the others. However, 5 of the 6 cases were related. Therefore, there was the possiblity of inheritance of a genetic factor which affected susceptibility.

¹ This study was supported by USPHS Research Grants CA 05924 and CA 07730 from the National Cancer Institute.

Received 2/20/67. Accepted 4/ 7/67.

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