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Induction and Maintenance of Tolerance to Jensen Tumors in Mice

The Medicine and Pharmacy Institute, Spitalul Clinic Panduri, and the Institute of Inframicrobiology of the Romanian Academy, Bucharest, Romania

Tolerance to Jensen rat tumors could not be induced by the administration of rat spleen cells and/or Jensen tumor cells, to newborn mice, during the first day of life. When the same total dose of tumor cells (in a pure suspension or mixed with spleen cells) was administered in three successive injections on the first three days of life, it induced the formation of Jensen tumors that developed over a period of 10 days, after which rejection set in. Actively developing tumors appeared when Jensen tumor cells were reinoculated before the 12th day of life in mice that had not displayed tumors following neonatal treatment, or before the 15th day of life in mice that had rejected the tumors induced by neonatal treatment. These results suggest that the induction and persistance of tolerance to rat Jensen tumors are dependent on the repeated exposure of suckling mice to the heterospecific antigenic stimulus.

Received 1/26/66. Accepted 4/ 5/67.