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Biology of the Prostate Gland: The Electron Microscopy of Cytoplasmic Filamentous Bodies in Human Benign Prostatic Cells Adjacent to Cancerous Cells¹

Department of Pathology and Urology, Squier Urological Clinic, College of Physicians and Surgeons, Columbia University, New York, New York 10032

Multiple blocks of tissue from hyperplastic and carcinomatous prostatic glands were studied with the electron microscope. The surface lining cells of the hyperplastic glands adjacent to foci of carcinoma frequently contained juxtanuclear cytoplasmic filamentous bodies. These filamentous bodies were composed of filaments 350 Å in diameter which were, for the most part, regurlarly arrayed. These filamentous structures were absent in the following cell types: (a) carcinomatous cells, (b) hyperplastic glands of non-neoplastic prostates, and (c) hyperplastic glands in neoplastic prostates which were distant from the malignant foci. The significance of these cytoplasmic filamentous structures is at present obscure.

¹ This work has been supported by grants from the John A. Hartford Foundation Inc., and Irene Given and John La Porte Given Foundation and by USPHS Grants 5-TIGM-865-04, HE-5906, and N. Y. C.-V10-75.

Received 10/10/66. Accepted 4/ 7/67.