This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Toth, B. Search for Related Content PubMed PubMed Citation Articles by Toth, B.

Studies on the Incidence, Morphology, Transplantation, and Cell-free Filtration of Malignant Lymphomas in the Syrian Golden Hamster¹

The Chicago Medical School, Institute for Medical Research, Division of Oncology, Chicago, Illinois 60612

The spontaneous occurrence and the detailed histopathologic description of malignant lymphomas in control Syrian golden hamsters are presented. The tumors appeared during the second half of the hamsters' lives and were diagnosed as malignant lymphomas, histiocytic type, histologically involving the lymph nodes, skin, liver, spleen, and kidney.

Homologous transplantation studies were carried out; in the adult animals the tumor cell graft failed to grow, while in neonatal animals, eight subsequent transplant generations were obtained by the inoculation of tumor cell suspensions.

Cell-free filtration attempts were performed also, one from the original and four from the transplanted tumor cells, without any detectable results.

Possible causative factors which may play a role in the development of this tumor are discussed.

¹ These studies were supported by Grants CA-4665, CS-9212, and Contract PH-43-65-67 from the National Cancer Institute, NIH, USPHS.

Received 12/ 2/66. Accepted 4/11/67.