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Glutaminase Activities in Normal and Neoplastic Tissues of the Rat¹

Department of Biological Chemistry, Harvard Medical School, and the Cancer Research Institute, New England Deaconess Hospital, Boston, Massachusetts 02215

Inherent and phosphate-activated glutaminases were present in 7 primary and transplanted rat tumors in amounts within the range covered by normal tissues. The activities found were approximately proportional to the growth rates of the tumors over a 3-fold range.

¹ This investigation was supported by USPHS Grant CA-06993, by Research Career Award AM-K6-2018 from the National Institute of Arthritis and Metabolic Diseases of the NIH, by a grant from the American Cancer Society (Massachusetts Division), Inc., and by U. S. Atomic Energy Commission Contracts AT(30-1)-3777 and AT(30-1)-3779 with the New England Deaconess Hospital. Dr. Tremblay is supported by American Cancer Society Fellowship PF-274.

² Present address: Department of Biochemistry, University of Rhode Island, Kingston, Rhode Island.

Received 3/14/67. Accepted 4/18/67.