This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Smith, E. E. Articles by Rutenburg, A. M. Search for Related Content PubMed PubMed Citation Articles by Smith, E. E. Articles by Rutenburg, A. M.

Aspartate Transcarbamylase in Normal and Neoplastic Human Colon¹

Yamins Laboratory for Surgical Research, Beth Israel Hospital, and Department of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215

Qualitative and quantitative studies on crude preparations of aspartate transcarbamylase from normal and neoplastic human colon were carried out. Whereas the activity of the enzyme was markedly higher in neoplastic tissue, no qualitative differences were observed between the enzymes from the two types of tissues. Negative feedback inhibition of human colon aspartate transcarbamylase could not be demonstrated.

¹ Supported by Grants CA-02528 and CA-02972 and Contract PH 43-63-1154 from the National Cancer Institute, NIH, USPHS, Bethesda, Maryland.

Received 10/ 7/66. Accepted 4/18/67.