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Increased Susceptibility to Low Doses of a Carcinogen of Epidermal Cells in Stimulated DNA Synthesis¹

Department of Pathology, Faculty of Medicine, McGill University, Montreal, Canada

The increased susceptibility of epidermal cells to a carcinogen following a single prior treatment with croton oil and its correlation with increased DNA synthesis following croton oil was confirmed.

The effect of croton oil on DNA synthesis was local rather than systemic, just as Pound found its effect on increased susceptibility to a carcinogen to be local rather than systemic.

The effect of prior treatment with croton oil was diminished and finally obliterated by increasing dosages of the carcinogen.

¹ This work was supported by a grant of the National Cancer Institute of Canada.

² Present address: Cancer Research Laboratory and Department of Pathology, University of Western Ontario, London, Ontario, Canada.

³ Present address: Department of Pathology, School of Medicine, Padjadjaran State University, Bandung, Indonesia.

Received 11/25/66. Accepted 4/20/67.