This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Eshelman Miller, E. Articles by Tsou, K. C. Search for Related Content PubMed PubMed Citation Articles by Eshelman Miller, E. Articles by Tsou, K. C.

Immunity to Lymphoma Induced by Diallyl ß-Aziridinopropionamide in Inbred Rats¹

The Harrison Department of Surgical Research, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Diallyl ß-aziridinopropionamide (DAAP) was found to be effective in causing complete regression of Lymphoma 8, a malignant tumor of Lewis-Wistar inbred rats, which killed all control animals in 10–13 days. No recurrence of lymphoma was noted after an observation period of 10 months. At that time animals in which lymphoma had regressed and the group of normal controls were given a large challenge inoculation of lymphoma. Six animals in which lymphoma regression had been induced by treatment with DAAP rejected the challenge implant. Seventeen control animals, including those uninjected normals which were carried through the observation period and those injected with DAAP or 0.9% NaCl, died in 10–13 days from the lymphoma challenge transplant.

¹ Supported in part by USPHS Grants CA-07339 and FR-5415 and the S & H Riesman Labold Fund.

Received 3/23/67. Accepted 4/18/67.