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Nucleic Acid and Protein Synthesis of Malignant Ascites Cells in the Presence of Liver Extract and Methylglyoxal¹

Institute for Muscle Research at the Marine Biological Laboratory, Woods Hole, Massachusetts 02543

The action patterns of methylglyoxal and a particular protein fraction from normal liver on protein, RNA, and DNA synthesis of Sarcoma 180 and Krebs 2 ascites cells were investigated. Results show that their inhibitory actions are distinctly different. Methylglyoxal preferentially inhibits protein synthesis, while the protein fraction of the liver acts on DNA and RNA synthesis.

¹ This research was supported by the NIH, Grant No. GM-10383.

Received 12/19/66. Accepted 4/19/67.