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Screening Data from the Cancer Chemotherapy National Service Center Screening Laboratories. XLIII

Data are reported on 1592 synthetic compounds which were tested in the CCNSC primary screens. Almost all of the compounds were tested in Sarcoma 180, Adenocarcinoma 755, Leukemia 1210, and KB cells in culture; some tests were also carried out in Friend virus leukemia, Ehrlich ascites, Human epidermoid carcinoma HEp2, Lewis lung carcinoma, and Walker 256 (intramuscular). Data are reported only on compounds which have not demonstrated sufficient activity in these systems to warrant further investigation. The number of test systems in the screening program has been reduced; the reasons for the reduction are discussed.

¹ Chief, Cancer Chemotherapy National Service Center, National Cancer Institute, Public Health Service, Bethesda, Maryland 20014.

² Biologist, Screening Section, Drug Evaluation Branch, Cancer Chemotherapy National Service Center, National Cancer Institute, Public Health Service, Bethesda, Maryland 20014.

³ National Libarary of Medicine, Public Health Service, Bethesda, Maryland 20014.