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Electron Microscopic Study of the Distribution of the Mouse Leukemia Virus (Gross) in Genital Organs of Virus-injected C3Hf Mice and of AK Mice¹

Cancer Research Unit, Veterans Administration Hospital, Bronx, New York 10468

An electron microscope study of the genital organs of male and female mice carrying the mouse leukemia virus revealed the presence of virus particles both in strain AK mice which naturally carry the virus, and in C3Hf mice injected with the virus. There was no significant difference in the distribution and quantity of particles observed in the genitals of AK and virus-injected C3Hf mice.

The virus particles appeared in ovaries, oviducts, uteri, epididymis, vas deferens, seminal vesicles, and prostate of nonleukemic and leukemic AK mice and virus-injected nonleukemic and leukemic C3Hf mice. In general, a greater number of particles appeared in the genital organs of leukemic than nonleukemic virus-injected animals. Budding of particles was observed from cells of the theca folliculi and corpus luteum of ovaries, and from epithelial cells and connective tissue fibroblasts of other genital organs. Occasionally, particles appeared to form from endothelial cells of capillaries and arterioles of ovaries or testes, from smooth muscle cells of arterioles of ovaries, and from smooth muscle cells of oviducts. Doughnut-type particles and particles with nucleoids were usually present in intercellular spaces or lying free within the tubular or glandular lumen of various organs.

Normal noninjected C3Hf male and female mice were also studied, but no virus particles were noted in any of the genital organs examined.

¹ Aided, in part, by grants from the Damon Runyon Memorial Fund and the American Cancer Society.

Received 12/19/66. Accepted 4/27/67.

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