This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Halliburton, I. W. Articles by Thomson, R. Y. Search for Related Content PubMed PubMed Citation Articles by Halliburton, I. W. Articles by Thomson, R. Y.

The Effect of Diet and of Unilateral Nephrectomy on the Composition of the Kidney

Department of Biochemistry, The University of Glasgow, Glasgow, Scotland

In rats, unilateral nephrectomy is followed within 36 hours by a fall in the DNA concentration and a rise in the RNA/DNA and protein/DNA ratios in the remaining kidney. The changes in DNA concentration and in RNA/DNA ratio take place regardless of whether the animal is fed or fasted postoperatively; the increase in protein/DNA ratio takes place only if the animal is fed. Changes similar to but not identical with those produced by unilateral nephrectomy can be produced in the kidneys of intact rats by administering ammonium chloride in the diet for 6 days in amounts sufficient to cause acidosis. Equivalent amounts of sodium chloride or ammonium citrate do not produce these effects.

¹ Present address: McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706.

Received 11/14/66. Accepted 5/11/67.