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The Effect of Anticoagulants on the Volume of Normal and Leukemic Leukocytes¹

Department of Gynecology and Obstetrics and Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53706

Human leukocytes from allegedly healthy subjects and from patients with leukemia and Hodgkin's disease were measured on the Coulter counter and size distribution plotter before and after exposure to a variety of anticoagulants. Cell loss of healthy leukocytes was observed after exposure to heparin but not to potassium ethylenediaminetetraacetate and other calciumbinding anticoagulants. This loss did not occur in the blood of patients with leukemia and with Hodgkin's disease.

¹ This work was supported by Grants GM 07838-07 and 5-F3-CA-29, 297-01 of the NIH, USPHS, and funds from the Ford Foundation.

Received 10/ 7/66. Accepted 4/27/67.