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Replication of Type C Virus Particles in Thymus Grafts of C57BL Mice Inoculated with Radiation Leukemia Virus¹

Department of Pathology, University of Utah College of Medicine, Salt Lake City, Utah 84112, and the Department of Radiology, Stanford University School of Medicine, Palo Alto, California 94305

Electron microscopy has demonstrated the replication of virus particles in considerable quantity in intrarenal thymus grafts in irradiated C57BL/Ka mice during the latent period of lymphoma induction by cell-free extracts of lymphomas similarly induced. The incidence of tumors was high and the latent period was short. The particles could not be found in similarly prepared control mice inoculated with saline and those mice did not develop lymphomas. Only one lymphoma developed in similar controls inoculated with heated cell-free extract, and no virus was found in those grafts. It is concluded that the lymphomagenic activity of cell-free extracts of radiation-induced lymphomas of C57BL mice is associated with a virus resembling other murine leukemia viruses. Reasons are quoted for regarding it as a distinct member of this group. The observations indicate that the virus replicates rapidly in regenerating thymus grafts.

¹ This investigation was supported by USPHS Research Grants CA 03352, CA 05008, CA 05321, and CA 06846 from the National Cancer Institute, NIH.

Received 2/ 9/67. Accepted 9/19/67.