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Transplantable Chondrosarcoma in the Syrian Hamster (Mesocricetus auratus)¹

Viral and Rickettsial Disease Laboratory, California State Department of Public Health, Berkeley, California 94704

A transplantable chondrosarcoma arose on the right humerus of a 6-month-old Syrian hamster in a breeding colony of 3000. After inoculating viable fragments by the cheek pouch route and administering cortisone in the first two passages, the neoplasm was transplanted successfully by subcutaneous inoculation, without the use of cortisone, in 220 of 251 animals through 17 passages over a period of 3.5 years.

The neoplasms were characterized by a well-defined capsule which enclosed a layer of anaplastic mesenchymal cells. These cells appeared to differentiate into neoplastic cartilage which underwent necrosis and developed mucus-filled cysts in the centers of the larger specimens.

The average rate of growth was variable among neoplasms, and no metastases were seen although local invasion was occasionally evident.

Antibodies were not found to the virions or tumor antigens of various oncogenic viruses, and neoplasms did not develop in hamsters inoculated with cell-free filtrates.

¹ This study was supported by Research Grant CA 07729 from the National Cancer Institute, NIH, U. S. Department of Health, Education and Welfare, Bethesda, Maryland.

Received 2/15/68. Accepted 5/19/68.