This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Olson, R. L. Articles by Everett, M. A. Search for Related Content PubMed PubMed Citation Articles by Olson, R. L. Articles by Everett, M. A.

An Electron Microscopic Study of Bowen's Disease¹

Department of Dermatology, University of Oklahoma Medical Center, Oklahoma City, Oklahoma

Bowen's disease was studied by electron microscopy. Conspicuous findings included: discontinuity of the basement membrane; cytoplasmic projections of epidermal cells through these breaks; widened intercellular spaces; a decrease in intact desmosomes some of which are apparently replaced by villous projections; an increased number of cytoplasmic organelles, many with an abnormal appearance; aggregation of tonofilaments and other organelles resulting in dyskeratosis; and increased nucleolar size and the observation of virus-like particles.

¹ This study was supported by American Cancer Society Grant #E-450.

Received 2/15/68. Accepted 5/23/68.