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Effect of Growth Hormone on Hepatic Carcinogenesis and Cirrhosis in AxC Rats Given N-2 Fluorenyldiacetamide

Laboratory of Biology, National Cancer Institute, Bethesda, Maryland 20014

Inbred AxC strain male and female rats were fed 0.025% N-2-fluorenyldiacetamide in the diet. Growth hormone was administered to intact and castrated animals to determine its effect on carcinogenesis and cirrhosis of the liver. Growth hormone increased the incidence of hyperplastic and neoplastic lesions and cirrhosis in both castrated males and castrated females, but it did not exert any effect in the intact animals.

Received 3/15/68. Accepted 8/ 1/68.