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The Effect of Manipulation and Incision on Experimental Carcinoma of Hamster Buccal Pouch¹

Department of Oral Pathology, Tufts University School of Dental Medicine, Boston, Massachusetts 02111

Sixty male and female golden hamsters, 6 months of age, were studied for the effects of incision and manipulation of buccal pouch carcinomas upon the growth and invasion of these malignant tumors. Epidermoid carcinomas were induced in the left buccal pouch by painting three times weekly with a 0.5% solution of 9,10-dimethyl-1,2-benzanthracene in heavy mineral oil. Carcinomas became grossly visible at 12 weeks. At this time, the 60 animals were divided into three equal groups. In 20 animals (Group A), no further treatment was carried out. In 20 animals (Group B), the left buccal pouch was everted and a 3-mm incision was made in the area of pathology. In 20 animals (Group C), the left pouch was everted and the tissue massaged and compressed with a tissue forcep. All animals were sacrificed at 18 weeks. No gross or microscopic differences were observed between the three groups in relation to tumor size, invasion, or extension. Metastasis was not observed in any of the groups.

¹ This project received support from Institutional Grant 23J from the American Cancer Society.

Received 1/25/68. Accepted 8/ 1/68.