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Interaction between Carcinogenic Hydrocarbons and Nucleosides¹

The Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Illinois 60637

Donor-acceptor complex formation between polycyclic aromatic hydrocarbons, carcinogenic and noncarcinogenic, and compounds of biologic importance is conveniently detected by chromatography of the former on thin layers of inert adsorbents impregnated with the latter. Among the compounds exhibiting significant interaction with aromatic hydrocarbons are adenosine, uridine, thymidine, guanosine, riboflavin, and caffeine. Although the potent carcinogenic compounds are all bound moderately well, the strength of binding is related more to the number of fused aromatic rings than to the reported carcinogenicity of the hydrocarbons.

¹ This investigation was supported in part by USPHS Grant CA-08674 from the National Cancer Institute.

Received 3/25/68. Accepted 8/ 1/68.