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Carcinogens from Fungi Pathogenic for Man¹

Skin and Cancer Hospital and Fels Research Institute, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140 [F. B., D. R. M., M. B. S., and R. W.] and Department of Chemistry, McGill University, Montreal, Canada [O. C., G. J.]

Cells of Candida parapsilosis were extracted sequentially with different organic solvents. The sodium carbonate wash of the methanol extract showed carcinogenic activity in mice as demonstrated by the appearance of 6 sarcomas at the site of injection in a group of 16 animals. Suggestive carcinogenic activity in the appearance of subcutaneous sarcomas and increased frequency of leukemias and pulmonary tumors was observed with lipid extracts of species of the genera Microsporum, Trichophyton, Epidermophyton, and Scopulariopsis.

¹ Supported in part by Contract PH-43-65-1029 and Grant CA-07174 from the NIH, USPHS.