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Physiologic Activity of Some Fungal Estrogens Produced by Fusarium¹

Department of Plant Pathology and College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota 55101

An estrogen (F-2) produced by Fusarium graminearum under natural conditions, causes marked uterotropic response in rats, mice, gilts, and guinea pigs and is suspected of contributing to problems of infertility in dairy cattle. Its range of biologic activity is quite broad. Besides its activity in animals, it also has a stimulating effect in bud initiation of tobacco pith callus tissue in culture and affects the sexual cycle of various fungi. Out of the study of the biosynthesis of F-2, four other estrogenic metabolites produced by F. graminearum have been discovered.

¹ Paper No. 6580, Scientific Journal Series, Minnesota Agricultural Experiment Station. Supported in part by USPHS Research Grant No. UI-00307-02 from the National Center for Urban and Industrial Health.