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The Carcinostatic Activity of 5-Hydroxy-2-formylpyridine Thiosemicarbazone¹

Chemotherapy Research Laboratory, Mount Zion Hospital and Medical Center, San Francisco, California 94115

5-Hydroxy-2-formylpyridine thiosemicarbazone (5-HP) is highly active intraperitoneally against leukemia L-1210, Ehrlich ascites carcinoma, and lymphoma L-5178Y over a broad dose range. 5-HP is also active on leukemia L-1210 and the Ehrlich ascites carcinoma by delayed treatment. Activity by oral routes or subcutaneously is poor. Moderate activity is displayed against the Lewis lung carcinoma and adenocarcinoma 755. 5-HP is the most active antileukemic agent in this series to date.

¹ This work was supported by Grant No. CA-03287 from the National Cancer Institute.

Received 4/16/67. Accepted 8/ 6/68.