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The Influence of Actinomycin D on Survival of X-radiated RF Mice

National Cancer Institute, NIH, Bethesda, Maryland 20014

The effect of a single dose of actinomycin D, given at the time of irradiation, on X-radiation-induced leukemia and lymphoma in RF mice was investigated. The mice were treated with 300 R and actinomycin D in combination and separately. As measured by survival analysis, actinomycin D alone did not change either the incidence of lymphomas and/or leukemia, nor the overall survival rates. In combination with X-radiation, actinomycin D was far more toxic in male than in female mice, as manifested by mortality within 30 days after irradiation; it had no effect, however, on subsequent survival nor any consistent effect on the incidence of leukemia. The lack of consistent effects of actinomycin D on long-term survival or on the incidence of leukemia possibly may be related to the time of its administration in relation to X-radiation.

Received 4/ 3/68. Accepted 8/ 7/68.