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Metabolic Properties of Mouse Transplantable Adenocarcinoma

Institute of General Pathology, University of Perugia, Scientific Department of Regina Elena Institute for Cancer Research, Rome, Italy, and University of Alabama Medical Center, Birmingham, Alabama

Some metabolic properties of a new, spontaneous, transplantable adenocarcinoma originating from a C3H mouse submaxillary gland have been analytically compared to the normal gland. The major findings may be summarized as follows: (a) The oxygen consumption of tumor cells is 38% higher than that of the normal gland. (b) In anaerobic conditions the normal submaxillary gland shows a higher degree of glycolysis, while in the presence of air it is unable to glycolyze. (c) The presence of pyruvate and fumarate greatly increases the oxygen consumption of tumor homogenate, while for the normal gland homogenate their utilization is very low. The diphosphopyridine nucleotide requirement for oxidation of pyruvate and fumarate is practically similar for the tumor and the normal gland.

The data obtained are evaluated in terms of their comparative significance and a tentative interpretation of the findings is suggested.

Received 3/ 4/68. Accepted 8/ 1/68.