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Neoplastic Response of Various Tissues to the Systemic Administration of the 8-Methyl Ether of Xanthurenic Acid¹

The Division of Clinical Oncology, University of Wisconsin Medical School, Madison, Wisconsin 53706

Following the repeated s.c. administration of an aqueous solution of the 8-methyl ether of xanthurenic acid into female Swiss mice, an incidence of 23% malignant tumors of the lymphoreticular system was observed. This incidence was significantly greater than the one of 4% found in a corresponding control group. Although other tumors — mammary adenoma, pulmonary adenoma, uterine fibroadenoma, etc. — were observed in both groups, no significant difference in incidence was apparent.

¹ Supported in part by Grant No. CA-10017 from the National Cancer Institute, USPHS; and by Grants Nos. E-115 and E-116H from the American Cancer Society.

Received 6/26/67. Accepted 10/ 2/67.