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Histochemical Changes during Rejection of C3H Ascites Tumor BP8 in C57BL Mice

Division of Immunology, Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27706

Alterations in cytoplasmic organelles of BP8 tumor cells during rejection in C57BL mice were followed by histochemical methods. By the third day after inoculation of the tumor the mitochondria assumed a smaller and less well defined appearance and clumps of host histiocytes and tumor cells became conspicuous. In such clumps intense metabolic activity was regularly observed and increased staining reactions of lysosomal enzymes were apparent in both the host and tumor cells. In the later stages of rejection the tumor cells were in free suspension and their cytoplasmic organelles showed diffuse degenerative changes. The reaction pattern was consistent with the view that many of the early alterations are induced following contact with host cells whereas later changes are induced by humoral factors.

¹ Supported by USPHS Grant 2G 516. Present address: Department of Surgery, Medical College of South Carolina, Charleston, S.C. 29401.

² Supported by USPHS Grant GM 22, 454-02.

³ Supported by USPHS Grants CA07371-04 and K6-AI-18399.

Received 4/11/67. Accepted 10/ 4/67.

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