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Prevention of Therapeutically Induced Regression of Sarcoma 180 by Immunologic Enhancement¹

Department of Experimental Therapeutic, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14203

The increased incidence of regression of Sarcoma 180 observed in Swiss HaICR mice fed vitamin B₆-deficient diet or treated with 6-mercaptopurine or kethoxal-bis(thiosemicarbazone) was greatly reduced by active immunization of the host with frozen-thawed Sarcoma 180 homogenate or by passive transfer of specific hyperimmune serum. Similar results were obtained in C57BL/6 mice implanted with a subline of Sarcoma 180 resistant to vitamin B₆ deficiency and treated with the 2 drugs. In vitamin B₆-deficient Swiss mice, immunization with frozen-thawed homogenate heated at 57°C for 30 minutes or with homogenates of DBA/2Ha-DD spleen, thymus and liver was also effective in reducing the incidence of regression of Sarcoma 180. Active immunization with homogenates of Walker carcinosarcoma 256 had no effect.

In contrast to the reduction of the incidence of regression mentioned, neither active nor passive immunization altered the growth inhibition of the tumors caused by the therapeutic treatments.

The evidence reported here indicates that active and passive immunologic enhancement of tumor growth can reduce the ultimate therapeutic effects of selective antitumor treatments.

¹ This investigation was supported in part by a research grant (CA-04130) from the National Cancer Institute, USPHS, and by an Institutional Research Grant (1-SOI-FR-5562-03) from the USPHS.

² Present address: Department of Radiology, Stanford University Medical School.

Received 6/14/67. Accepted 10/ 6/67.

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