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A Clinical Evaluation of Dose and Schedule of Administration of Cytosine Arabinoside (NSC 63878)

Baltimore Cancer Research Center, USPHS Hospital, Baltimore, Maryland, and the National Cancer Institute, Bethesda, Maryland 20014

Cytosine arabinoside (1-β-D-arabinofuranosylcytosine hydrochloride) was given to 24 patients with varied tumors for 32 trials in a study designed to compare toxicity of continuous infusion and single daily injections for a 5-day period. At low dose ranges of 50 and 100 mg/sq m, continuous infusion produced greater bone marrow depression than single injections. However, as dosage was increased from 150 to 300 mg/sq m, equal depression was encountered with either schedule. Increasing the dose to 400 and 600 mg/sq m by injection produced no further myelosupression. Except for mild nausea and occasional vomiting, no other toxicity was encountered. The importance of varying treatment schedules in cancer chemotherapy is discussed.

¹ Present address: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

Received 3/17/67. Accepted 10/ 7/67.

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