This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Murdock, D. K. Articles by Calabresi, P. Search for Related Content PubMed PubMed Citation Articles by Murdock, D. K. Articles by Calabresi, P.

Studies on the Kinetics of Marrow Regeneration after Local Irradiation of the Femur in Rabbits¹

Departments of Medicine, Pharmacology, and Radiology, Yale University School of Medicine, New Haven, Connecticut 06510

The development of 2 laboratory technics for more accurate quantification of hematopoietic activity, (a) radioactive iron (⁵⁹Fe) uptake and (b) DNA content of marrow cells, are described, utilizing a regenerating marrow system in rabbits after local irradiation of 1 femur while shielding the contralateral leg. The sensitivity and reproducibility of the 2 methods were determined; there was good correlation of the results obtained with these 2 technics. The significance of these tests of bone marrow activity as useful indicators in the experimental evaluation of new myelosuppressive agents is discussed.

¹ This work was supported in part by USPHS Grants CA-5944, CA-5138, CA-8341, and CA-6519.

² Present address: Children's Hospital of Michigan, 5224 St. Antoine Street, Detroit, Michigan 48202.

³ Burroughs Wellcome Scholar in Clinical Pharmacology.

Received 6/23/66. Accepted 10/12/67.