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Criteria for Evaluating Hormones in the 7,12-Dimethylbenz[a]anthracene-induced Mammary Tumor-rat Experimental Chemotherapy System¹

Divisions of Experimental Chemotherapy and Chemotherapy Research, Sloan-Kettering Institute for Cancer Research, New York, New York 10021

Two criteria were used to measure the effectiveness of hormones in the therapy of mammary tumors induced in Sprague-Dawley rats by 7,12-dimethylbenz[a]anthracene. These were complete regression of all tumors in the host and duration of complete remission. Well-established, growing mammary tumors were treated with testosterone propionate or 2-methyldihydrotestosterone propionate. There was no significant difference between the effects of the two androgens, at equivalent doses, with respect to production of complete remissions. However, the median for duration of complete remission in rats treated with 2-methyldihydrotestosterone propionate was significantly greater than for testosterone propionate. The results suggest that duration of remission is a useful adjunct for disclosing differences between compounds with similar abilities to cause tumor regression.

¹ Supported by Contracts SA-ph-2445 and PH 43-65-619 from the Cancer Chemotherapy National Service Center, National Cancer Institute, NIH, USPHS, and by National Cancer Institute Grant CA 08748.

Received 7/ 5/67. Accepted 10/21/67.