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A Qualitative Study of Normal Leukocyte Antigens of Human Leukemic Leukoblasts¹

Institut de Recherches sur les Maladies du Sang, Hôpital Saint-Louis, Paris 10ème, France

Twelve leukocyte antigens have been determined by the method of cytotoxicity in vitro on leukoblasts from 38 patients with acute leukemia, using two batteries of isoimmune human sera. None of these antigens was absent in this leukemic population. The presence of the leukocyte antigens 1, 3, 4, 6, and 7 of the Hu-1 system (5) was confirmed by absorption experiments. In 17 patients, the leukocyte group defined on leukoblasts during the acute phase of the disease was found to be identical to that determined on lymphocytes from the same patients during the remission period. No qualitative antigenic alterations of these alloantigens were found on the leukoblasts from patients with acute leukemia.

¹ Supported by the Centre National de la Recherche Scientifique (Associated Laboratory No. 47), by Research Grant CA 5573 from the National Cancer Institute, and by Contract PH 43 65 986 from the National Institute of Allergy and Infectious Diseases, USPHS.

Received 7/17/67. Accepted 10/22/67.