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The Syndrome of Inappropriate Secretion of Antidiuretic Hormone: A Case Report and Characterization of an Antidiuretic Hormone-like Material Isolated from an Oat Cell Carcinoma of the Lung

Baylor University College of Medicine, and M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025

This paper presents a report of a patient with the syndrome of inappropriate secretion of antidiuretic hormone associated with an oat cell carcinoma of the lung. Antidiuretic activity was found on bioassay of plasma and tumor extracts. The active material could be extracted from the tumor by procedures known to isolate the native human peptide, arginine vasopressin. The material passed through a Sephadex G-25 column with a V_e/V_o ratio identical to that of vasopressin; on counter-current distribution, the material possessed a partition coefficient identical to that of purified arginine vasopressin.

¹ This study was supported in part by USPHS Grant AM-04122 and American Cancer Society Institutional Research Grant ACSIN-27-G-Project 1.

² Supported by NATO postdoctoral fellowship.

Received 6/12/67. Accepted 10/22/67.