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Effects of Dietary Fat on the Uptake and Clearance of 7,12-Dimethylbenz()anthracene by Rat Mammary Tissue¹

The Department of Obstetrics and Gynecology and the Collip Medical Research Laboratory, University of Western Ontario, London, Canada

The concentration of 7,12-dimethylbenz()anthracene (DMBA) in mammary tissue was determined at different time intervals following its administration, in a single dose, to female Sprague-Dawley rats maintained on 3 different semisynthetic diets: low fat, high coconut oil, and high corn oil. In general, the rate of uptake and clearance of the carcinogen was similar in the 3 groups, with a peak concentration occurring 6 to 12 hours after its administration. At 6 hours the tissue level of DMBA in coconut oil fed rats was significantly lower than in the other 2 groups. However, the data obtained could not fully explain the effects of dietary fat upon DMBA mammary carcinogenesis.

¹ This study was supported by a grant from the Ontario Cancer Treatment and Research Foundation.

² Medical Research Associate, Medical Research Council of Canada.

Received 6/28/67. Accepted 10/14/67.

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