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Effect of -Methyl-p-tyrosine on 3,4-Dihydroxyphenylalanine (DOPA) Excretion of Hamsters with Melanotic Melanoma¹

Department of Pediatrics, State University of New York, Upstate Medical Center, Syracuse, New York 13210

Fortner melanotic melanoma type 1 was transplanted subcutaneously into the flank of golden Syrian female hamsters. Five to 8 days later tumor growth was visible to the unaided eye and 3,4-dihydroxyphenylalanine (DOPA) was found in the urine. As the melanoma increased in size DOPA excretion also increased. Treatment with intraperitoneal injections of L--methyl-p-tyrosine beginning 7–10 days after transplant was associated with marked decrease in urinary DOPA output and retardation of tumor growth.

¹ This work was supported by USPHS Research Career Program Award Ca-K3-14,289 and Research Grant CA-06312 from the National Cancer Institute.

Received 9/ 8/67. Accepted 10/28/67.