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The Effect of a Hydrocarbon-enriched Fraction of Cigarette Smoke Condensate on Human Fetal Lung Grown in Vitro

Strangeways Research Laboratory, Cambridge, England

The effect of a hydrocarbon-enriched fraction from cigarette smoke condensate on human fetal lung grown in organ culture was studied. The lungs were derived from fetuses of 18 and 32 weeks gestation. The compound promoted the growth of new bronchi, caused cellular enlargement, stimulated mitosis, and induced hyperplasia of the bronchial epithelium in up to 100% of the treated explants. The hyperplastic epithelium underwent squamous metaplasia or showed cytologic changes compatible with malignant transformation.

In the younger tissue the hyperplasia was widespread and occurred in bronchi of all sizes; in the older tissue it was seen mainly in the larger bronchi.

The results suggest that the hydrocarbons in cigarette smoke play an essential role in the development of human lung cancer.

¹ Sir Halley Stewart Fellow.

Received 7/ 5/67. Accepted 11/ 6/67.

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