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Virus Particles in Renal Tumors Obtained from Spring Rana pipiens of Known Geographic Origin¹

Department of Biology, Newcomb College of Tulane University, New Orleans, Louisiana 70118, and Department of Anatomy, University of Colorado Medical Center, Denver, Colorado 80220

Virus particles were found to be characteristically associated with spontaneous renal adenocarcinoma cells obtained from Rana pipiens collected from several localities in Minnesota during early spring 1967 while the afflicted frogs were still in overwintering lakes or in breeding ponds. The lake water temperature from which the tumor-bearing frogs were obtained was 2–7°C. Eleven renal tumors were examined with the electron microscope; intranuclear, cytoplasmic, and extracellular virus particles were observed. One renal tumor was studied with the light microscope only; its histology resembled that of tumors of frogs maintained in a cold laboratory environment.

These results are in contrast to the variable cytology and fine structure reported concerning renal tumors obtained in frogs from commercial sources.

¹ Supported by American Cancer Society Research Grant E-369-A (R.G.M.) and University of Colorado Medical Center Research Grant GRS-325 Fluid Research (J.Z.).

Received 8/28/67. Accepted 12/25/67.