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Experimental Transmission of Canine Malignant Lymphoma to the Beagle Neonate¹

Departments of Veterinary Surgery and Medicine and of Pathology, Michigan State University, East Lansing, Michigan 48823

Two serial passages of canine malignant lymphoma (CML) were accomplished in 2 litters of Beagle neonates with suspensions of viable CML whole cells. In these experiments 3 of 15 dogs inoculated with a single dose of either a cell suspension or a cell-free extract developed malignant lymphoma at 50, 53, and 80 days postinoculation. Two dogs with overwhelming CML were preirradiated, while one dog was not X-irradiated. Thus, a significant feature of this work was the successful transmission of CML without pretreatment of total-body irradiation. Malignant lymphoma did not occur in the third serial passage, although animals had enlargement of the superficial lymph nodes. Biopsies of these enlarged lymph nodes revealed lymphoid hyperplasia but not malignant lymphoma. The clinical signs and pathologic lesions were similar to those reported for naturally occurring malignant lymphoma of dogs and cats. Electron microscopic examination revealed intracytoplasmic structures which were made up of individual particles that measured 18 to 22 mµ in diameter.

¹ This investigation was supported in part by a USPHS postdoctoral fellowship 5-F3-CA-33, 786-02 from the National Cancer Institute and was conducted under Contract PH43-65-100 within the Special Virus Leukemia Program of the National Cancer Institute, NIH, USPHS.

² A portion of this work is in partial fulfillment of the requirements for the Ph.D. degree in pathology at Michigan State University.

Received 8/ 4/67. Accepted 12/28/67.

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