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The Mitotic Cycle of Sarcoma 180¹

Kettering-Meyer Laboratory, Southern Research Institute,² Birmingham, Alabama 35205

The mitotic cycle of proliferating cells in Sarcoma 180 solid tumors was analyzed by following the incidence of labeled mitoses with time. The method utilized a dispersed cell preparation treated to demonstrate mitotic figures. The average lengths of the cycle and its phases in hours were: total cycle, 13.5; S, 7.8; G₂, 2.5; G₁, 2.7; mitosis, approximately 0.5.

¹ This investigation was supported in part by Contract PH43-66-29 with the Cancer Chemotherapy National Service Center, National Cancer Institute, NIH, Bethesda, Maryland, and in part by funds made available by Southern Research Institute.

² Affiliated with Sloan-Kettering Institute for Cancer Research, New York, N. Y.

Received 9/25/67. Accepted 12/28/67.