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Effect of Protein Hydrolysate Administration on Liver Composition

Department of Biochemistry, The University, Glasgow, Scotland

Intravenous administration of a 10% protein hydrolysate to adult female rats at a level of 1 gm protein/kg body weight/hour over 12 hours was followed by significant increases in the average content of RNA per cell in the liver. Similar but larger increases in RNA per cell were obtained after 44 or 48 hours intraperitoneal administration at the same level, accompanied this time by a significant increase in mitotic activity. Investigation of the time course of these changes showed that RNA per cell increased sharply during the first 24 hours of treatment and again between the 38th and 42nd hours, but that mitotic activity did not increase until about 48 hours. The protein content per cell showed the same pattern of increase as RNA, but the changes were less clear-cut.

¹ Present address: Department of Biochemistry, Western Infirmary, Glasgow W. 1, Scotland.

Received 4/12/67. Accepted 12/29/67.